p-S516-ARHGEF7 activates RAC1

Stable Identifier
R-HSA-9619803
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p-S516-ARHGEF7 activates RAC1
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CAMK1-mediated phosphorylation of ARHGEF7 (Beta-Pix) at serine S516 enhances guanine nucleotide exchange factor (GEF) activity of ARHGEF7, leading to RAC1 activation. RAC1 and its downstream effector PAK1 are involved in NMDA receptor activity-dependent synaptogenesis (Saneyoshi et al. 2013).
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Output
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Catalyst Activity

guanyl-nucleotide exchange factor activity of GIT1:p-S516-ARHGEF7-1 [cytosol]

Physical Entity
GIT1:p-S516-ARHGEF7-1 [cytosol] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
p-S516-Arhgef7 activates Rac1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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