p-S516-ARHGEF7 activates RAC1

Stable Identifier
R-HSA-9619803
Type
Reaction
Species
Homo sapiens
Compartment
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CAMK1-mediated phosphorylation of ARHGEF7 (Beta-Pix) at serine S516 enhances guanine nucleotide exchange factor (GEF) activity of ARHGEF7, leading to RAC1 activation. RAC1 and its downstream effector PAK1 are involved in NMDA receptor activity-dependent synaptogenesis (Saneyoshi et al. 2013).

Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of GIT1:p-S516-ARHGEF7-1 [cytosol]

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