Reactome | Prkab1 [cytosol]

Prkab1 [cytosol]

Stable Identifier

R-RNO-9619496

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

5'-AMP-activated protein kinase subunit beta-1, AAKB1_RAT

Locations in the PathwayBrowser

Expand all

Autophagy (Rattus norvegicus)

- Macroautophagy (Rattus norvegicus)
  - AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - ULK complex translocates to the ER (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - ULK1 phosphorylates Beclin-1 (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - p-AMPK:AMP binds the ULK complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
    - p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
      - p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - TP53 Regulates Metabolic Genes (Rattus norvegicus)
        
        SESN1,2,3 bind AMPK (Rattus norvegicus)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)
        
        p-AMPK phosphorylates TSC1:TSC2 (Rattus norvegicus)
        
        p-AMPK heterotrimer:AMP [cytosol] (Rattus norvegicus)
        
        p-AMPK heterotrimer [cytosol] (Rattus norvegicus)
        
        AMPK beta [cytosol] (Rattus norvegicus)
        
        Prkab1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P80386 Prkab1

Gene Names

Prkab1

Chain

initiator methionine:1, chain:2-270

Reference Genes

BioGPS Gene:83803 Prkab1

KEGG:rno:83803 Prkab1

Monarch:83803 Prkab1

NCBI Gene:83803 Prkab1

UCSC:P80386 Prkab1

Reference Transcript

Other Identifiers

10758940

1386945_a_at

17674397

6025113

6041588

6203234

6240472

6428678

6544397

6589740

6632768

6648226

6707188

83803

A_44_P1056161

GE22211

GO:0005515

GO:0005634

GO:0031588

GO:0031669

GO:0035878

GO:0048856

GO:0120162

PH_rn_0004776

X95577_at

Participates

as a component of

as a member of

AMPK beta [cytosol] (Rattus norvegicus)

Other forms of this molecule

Prkab1 [endoplasmic reticulum lumen]

Prkab1 [nucleoplasm]

Inferred From

PRKAB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_114182.2, XP_006249543.1

ENSEMBL

ENSRNOP00000001508, ENSRNOT00000001508, ENSRNOG00000001142

PRO

P80386

RGD

71057

PDB

4QFS, 6E4U, 1Z0M, 1Z0N, 4YEF, 4QFR, 4QFG, 4EAG, 5T5T, 4EAL, 6E4T, 4EAK, 6E4W, 5KQ5, 5UFU

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O18645	7	PRKAA2 [nucleoplasm] (R-DME-163682) phospho-p-T172-PRKAA2 [nucleoplasm] (R-DME-164171) phospho-p-T183-PRKAA1 [nucleoplasm] (R-DME-2151206) PRKAA1 [cytosol] (R-DME-380935) phospho-p-T183-PRKAA1 [cytosol] (R-DME-380964) phospho-p-T172-PRKAA2 [cytosol] (R-DME-200417) PRKAA2 [cytosol] (R-DME-200405)	0.591	3

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