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MAP2K1 [cytosol]
Stable Identifier
R-RNO-59502
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q01986
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
MAPK3 (ERK1) activation (Rattus norvegicus)
Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)
MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
MAP2K1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q01986
Reference Genes
BioGPS Gene:170851
ENSEMBL:ENSRNOG00000010176
ENSEMBL:ENSRNOG00055024284
ENSEMBL:ENSRNOG00060018969
ENSEMBL:ENSRNOG00065006381
KEGG:rno:170851
Monarch:170851
NCBI Gene:170851
UCSC:Q01986
Reference Transcript
RefSeq:NM_031643.4
Other Identifiers
10918209
1367760_at
170851
17853443
5702059
5764462
5920090
6120083
6137419
6172334
6175246
6289679
6398139
6406479
6407949
6436589
6640283
6644163
A_44_P531063
D14591_s_at
GE22249
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005078
GO:0005524
GO:0005634
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005938
GO:0006355
GO:0006468
GO:0007507
GO:0008285
GO:0010628
GO:0010629
GO:0014044
GO:0016020
GO:0016301
GO:0016740
GO:0021697
GO:0021953
GO:0030154
GO:0030216
GO:0030295
GO:0030878
GO:0032872
GO:0035987
GO:0036064
GO:0038133
GO:0042552
GO:0043410
GO:0043539
GO:0044342
GO:0045893
GO:0048009
GO:0048538
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060020
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0060674
GO:0060711
GO:0070371
GO:0070374
GO:0090170
GO:0090398
GO:0097110
GO:0098772
GO:0140096
GO:1903226
GO:2000641
ILMN_1361975
L04485mRNA_s_at
PH_rn_0006352
Participates
as a member of
MAP2K1 [cytosol] (Rattus norvegicus)
as a component of
MAP2K1 dimer [cytosol] (Rattus norvegicus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
phospho-p-T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
phospho-p-S218,S222-MAP2K1 [cytosol]
Inferred From
MAP2K1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSRNOT00000120242
,
ENSRNOP00000084527
,
ENSRNOG00000010176
PRO
Q01986
RGD
70495
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