Reactome | phospho-p-S,218, S222,T292 MAP2K1 [cytosol]

phospho-p-S,218, S222,T292 MAP2K1 [cytosol]

Stable Identifier

R-RNO-5674490

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q01986

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - Negative regulation of MAPK pathway (Rattus norvegicus)
        
        Negative feedback regulation of MAPK pathway (Rattus norvegicus)
        
        Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)
        
        p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
        
        phospho-p-S,218, S222,T292 MAP2K1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q01986

Reference Genes

BioGPS Gene:170851

ENSEMBL:ENSRNOG00000010176

ENSEMBL:ENSRNOG00055024284

ENSEMBL:ENSRNOG00060018969

ENSEMBL:ENSRNOG00065006381

KEGG:rno:170851

Monarch:170851

NCBI Gene:170851

UCSC:Q01986

Reference Transcript

RefSeq:NM_031643.4

Other Identifiers

10918209

1367760_at

170851

17853443

5702059

5764462

5920090

6120083

6137419

6172334

6175246

6289679

6398139

6406479

6407949

6436589

6640283

6644163

A_44_P531063

D14591_s_at

GE22249

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005078

GO:0005524

GO:0005634

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006355

GO:0006468

GO:0007507

GO:0008285

GO:0010628

GO:0010629

GO:0014044

GO:0016020

GO:0016301

GO:0016740

GO:0021697

GO:0021953

GO:0030154

GO:0030216

GO:0030295

GO:0030878

GO:0032872

GO:0035987

GO:0036064

GO:0038133

GO:0042552

GO:0043410

GO:0043539

GO:0044342

GO:0045893

GO:0048009

GO:0048538

GO:0048679

GO:0048856

GO:0048870

GO:0050772

GO:0060020

GO:0060090

GO:0060324

GO:0060425

GO:0060440

GO:0060502

GO:0060674

GO:0060711

GO:0070371

GO:0070374

GO:0090170

GO:0090398

GO:0097110

GO:0098772

GO:0140096

GO:1903226

GO:2000641

ILMN_1361975

L04485mRNA_s_at

PH_rn_0006352

Participates

as a component of

p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-T286,T292-MAP2K1 [cytosol]

phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]

MAP2K1 [cytosol]

phospho-p-S218,S222-MAP2K1 [cytosol]

Inferred From

p-S,218, S222,T292 MAP2K1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 292 (in Homo sapiens)

Coordinate

292

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 218 (in Homo sapiens)

Coordinate

218

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 222 (in Homo sapiens)

Coordinate

222

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ENSEMBL

ENSRNOT00000120242, ENSRNOP00000084527, ENSRNOG00000010176

PRO

Q01986

RGD

70495

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