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Ptpn11 [cytosol]
Stable Identifier
R-RNO-548923
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Shp2, Tyrosine-protein phosphatase non-receptor type 11, PTN11_RAT, Shp-2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Tie2 Signaling (Rattus norvegicus)
Interaction of Tie2 and Shp2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
pTie2 and SHP2 complex [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
G6B binds PTPN6,PTPN11 (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
G6B:PTPN6,PTPN11 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CTLA4 inhibitory signaling (Rattus norvegicus)
SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PD-1 signaling (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP-1 and SHP-2 bind pBTLA (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon alpha/beta signaling (Rattus norvegicus)
Phosphorylation of STAT1 (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Regulation of IFNA signaling (Rattus norvegicus)
Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-20 family signaling (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN6,PTPN11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Interleukin-6 family signaling (Rattus norvegicus)
Interleukin-6 signaling (Rattus norvegicus)
PTPN11 binds CBL (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN11 binds p-Y759-IL6ST (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
PTPN11 is phosphorylated (Rattus norvegicus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF(TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Rattus norvegicus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
GAB1 signalosome (Rattus norvegicus)
Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
FRS-mediated FGFR1 signaling (Rattus norvegicus)
Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
FRS-mediated FGFR2 signaling (Rattus norvegicus)
Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
FRS-mediated FGFR3 signaling (Rattus norvegicus)
Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
FRS-mediated FGFR4 signaling (Rattus norvegicus)
Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS bind to PPTN11 (Rattus norvegicus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
Spry regulation of FGF signaling (Rattus norvegicus)
PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET activates PTPN11 (Rattus norvegicus)
GAB1 binds PTPN11 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
SHP2 binds to the active receptor (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP2 interacts with p-KIT (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
Ptpn11 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P41499 Ptpn11
Gene Names
Ptpn11
Chain
initiator methionine:1, chain:2-593
Reference Genes
BioGPS Gene:25622 Ptpn11
ENSEMBL:ENSRNOG00000030124 Ptpn11
KEGG Gene (Rattus norvegicus):25622 Ptpn11
Monarch:25622 Ptpn11
NCBI Gene:25622 Ptpn11
UCSC:P41499 Ptpn11
Reference Transcript
RefSeq:NM_013088.2 Ptpn11
RefSeq:NM_001177593.1 Ptpn11
Other Identifiers
10758727
10758744
1387668_at
1388379_at
17674151
25622
5701569
5784226
5806801
5838255
6066835
6185514
6247187
6254347
6265817
6295831
6326168
6356624
6379183
6398706
6659055
6684848
6693000
6726454
A_44_P317773
A_44_P460973
A_44_P999869
A_64_P004151
GE1283135
GE14369
GO:0000003
GO:0000077
GO:0000187
GO:0000278
GO:0000902
GO:0001784
GO:0002376
GO:0003674
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006464
GO:0006470
GO:0006629
GO:0006641
GO:0006810
GO:0006913
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0007173
GO:0007229
GO:0007267
GO:0007409
GO:0007420
GO:0007507
GO:0008150
GO:0008543
GO:0009755
GO:0009967
GO:0015031
GO:0016311
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0019904
GO:0021697
GO:0022607
GO:0030154
GO:0030159
GO:0030220
GO:0030674
GO:0030971
GO:0031748
GO:0032331
GO:0032528
GO:0032728
GO:0032755
GO:0032760
GO:0032991
GO:0033277
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035335
GO:0035855
GO:0036302
GO:0038127
GO:0040007
GO:0040011
GO:0042445
GO:0042592
GO:0042593
GO:0043226
GO:0043254
GO:0043274
GO:0043560
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048609
GO:0048646
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050731
GO:0050839
GO:0051428
GO:0051463
GO:0055085
GO:0060020
GO:0060125
GO:0060325
GO:0061582
GO:0065003
GO:0070374
GO:0071260
GO:0071364
GO:1990782
ILMN_1363069
PH_rn_0006733
PH_rn_0019279
U09307_at
U57499_at
U57499_g_at
rc_AI012725_s_at
rc_AI172465_at
Participant Of
input
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activation of SHP2 through the binding to phospho-Gab1
GAB1 binds PTPN11
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
Interaction of Tie2 and Shp2
Ntrk2-phosphorylated Frs2 binds Ptpn11
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
Prlr binds Shp2
PTPN11 binds p-Y759-IL6ST
Recruitment of Shp-2 to pSirp alpha
SHP2 binds to the active receptor
SHP2 interacts with p-KIT
SHP2 phosphatase binds CTLA-4
hasComponent
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane]
Activated FGFR1:p-FRS:PTPN11 [plasma membrane]
Activated FGFR2:p-FRS:PTPN11 [plasma membrane]
Activated FGFR3:p-FRS:PTPN11 [plasma membrane]
Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
BDNF:p-5Y-Ntrk2 homodimer:p-Y-Frs2:Ptpn11 [plasma membrane]
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane]
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane]
pCTLA-4:Src kinases:SHP2 [plasma membrane]
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane]
Prlr ligands:p(Y599)-Prlr:p(Y1007)-Jak2 dimer:Shp2 [plasma membrane]
pSirp alpha:Shp-2 [plasma membrane]
pTie2 and SHP2 complex [plasma membrane]
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane]
hasMember
PTPN6,PTPN11 [cytosol]
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
Other forms of this molecule
p-Y-Shp2 [cytosol]
Ptpn11 [nucleoplasm]
phospho-Ptpn11 [cytosol]
Inferred From
PTPN11 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_037220.2
,
NP_001171064.1
Ensembl
ENSRNOP00000041842
,
ENSRNOG00000030124
,
ENSRNOT00000046323
PRO
P41499
RGD
3447
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09619 PDGFRB
3
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.59
4
UniProt:P97710 Sirpa
9
Sirpa_Rat [plasma membrane]
(R-RNO-548921)
pSirpa_Rat [plasma membrane]
(R-RNO-548918)
phospho-Sirpa [plasma membrane]
(R-RNO-391102-6)
Sirpa [secretory granule membrane]
(R-RNO-6804801)
Sirpa [tertiary granule membrane]
(R-RNO-6803288-6)
Sirpa [ficolin-1-rich granule membrane]
(R-RNO-6803321-6)
Sirpa [plasma membrane]
(R-RNO-197568)
Sirpa [plasma membrane]
(R-RNO-3209922-6)
Sirpa [plasma membrane]
(R-RNO-197571-6)
0.544
3
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