Recruitment of Shp-2 to pSirp alpha

Stable Identifier
R-RNO-548968
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Recruitment of Shp-2 to pSirp alpha

SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.

Literature References
PubMed ID Title Journal Year
9507023 Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association

Stofega, MR, Wang, H, Ullrich, A, Carter-Su, C

J Biol Chem 1998
9582366 Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases

Tsuda, M, Matozaki, T, Fukunaga, K, Fujioka, Y, Imamoto, A, Noguchi, T, Takada, T, Yamao, T, Takeda, H, Ochi, F, Yamamoto, T, Kasuga, M

J Biol Chem 1998
Participants
Orthologous Events
Authored
Reviewed
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