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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
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Diseases
Cytomics
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Citing us
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Analyse gene expression
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Birc2 [cytosol]
Stable Identifier
R-RNO-50847
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
BIRC2, Q6P6S1
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Rattus norvegicus)
Cell junction organization (Rattus norvegicus)
Cell-cell junction organization (Rattus norvegicus)
Adherens junctions interactions (Rattus norvegicus)
Activation of STAT3 by cadherin engagement (Rattus norvegicus)
Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Rattus norvegicus)
RAC1,(CDC42) Ubiquitin Ligase [cytosol] (Rattus norvegicus)
(RAC1 E3 ubiquitin ligases) [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
TNFR2 non-canonical NF-kB pathway (Rattus norvegicus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAF3 binds BAFFR:BAFF (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAFs bind RANK:RANKL (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
RIP2 is K63 polyubiquitinated (Rattus norvegicus)
RIP2 ubiquitin ligases [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
IKK complex recruitment mediated by RIP1 (Rattus norvegicus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Rattus norvegicus)
RIP1 ubiqutin ligases [cytosol] (Rattus norvegicus)
c-IAP1:UBE2D [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)
HIF1A,BIRC2,BIRC3 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
USP19:HIF1A,BIRC2,BIRC3 [cytosol] (Rattus norvegicus)
HIF1A,BIRC2,BIRC3 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Apoptotic execution phase (Rattus norvegicus)
Apoptotic cleavage of cellular proteins (Rattus norvegicus)
Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
LUBAC ubiquitinates RIPK1 at K627 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Rattus norvegicus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Birc2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6P6S1
Gene Names
Birc2
Reference Genes
BioGPS Gene:60371 Birc2
ENSEMBL:ENSRNOG00000010602
KEGG:rno:60371 Birc2
Monarch:60371 Birc2
NCBI Gene:60371 Birc2
UCSC:Q6P6S1 Birc2
Reference Transcript
RefSeq:NM_021752.4 Birc2
RefSeq:NM_001431604.1 Birc2
Other Identifiers
10914788
1368291_at
17849414
5744629
5784401
5786327
5825327
5901021
5936281
60371
6147360
6171291
6220210
6289602
6294155
6329510
6447598
6473187
6531718
6570921
6585015
6668882
6672989
6708661
6713727
AF081503_at
A_44_P330542
GE20794
GE21390
GO:0000209
GO:0001890
GO:0003713
GO:0003824
GO:0004842
GO:0005634
GO:0005737
GO:0007249
GO:0008270
GO:0009898
GO:0016740
GO:0030163
GO:0035631
GO:0042802
GO:0042981
GO:0043066
GO:0043123
GO:0043124
GO:0043130
GO:0043161
GO:0048856
GO:0051087
GO:0051726
GO:0060544
GO:0060546
GO:0070266
GO:0071356
GO:0098770
GO:0140096
GO:1901222
GO:1902443
GO:1902523
GO:1902524
GO:1902527
GO:1902916
GO:2000377
PH_rn_0013497
Participates
as a member of
HIF1A,BIRC2,BIRC3 [cytosol] (Rattus norvegicus)
cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
as a candidate of
(RAC1 E3 ubiquitin ligases) [cytosol] (Rattus norvegicus)
RIP2 ubiquitin ligases [cytosol] (Rattus norvegicus)
as an input of
Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)
as a component of
c-IAP1:UBE2D [cytosol] (Rattus norvegicus)
Other forms of this molecule
Birc2 [cytosol]
Birc2 [cytosol]
Birc2 [cytosol]
Birc2 [cytosol]
Inferred From
BIRC2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001418533.1
,
NP_068520.2
ENSEMBL
ENSRNOG00000010602
,
ENSRNOT00000014560
,
ENSRNOP00000014560
RGD
620690
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