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BIRC2,3,4 [cytosol]
Stable Identifier
R-RNO-5357900
Type
Set [CandidateSet]
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
TNFR2 non-canonical NF-kB pathway (Rattus norvegicus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF3 binds BAFFR:BAFF (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAFs bind RANK:RANKL (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signalling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CLIP3 and CYLD bind TNF signaling complex (Rattus norvegicus)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
RIPK1 is deubiquitinated (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Rattus norvegicus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFR1-induced NFkappaB signaling pathway (Rattus norvegicus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Participants
members
Birc2 [cytosol] (Rattus norvegicus)
Birc3 [cytosol] (Rattus norvegicus)
candidates
Xiap [cytosol] (Rattus norvegicus)
Participant Of
hasComponent
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
TRAF2:cIAP1,2 [cytosol]
input
BIRC2/3 (cIAP1/2) is autoubiquitinated
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
Inferred From
BIRC2,3,4 [cytosol] (Homo sapiens)
cIAP1,2 [cytosol] (Homo sapiens)
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