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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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BIRC2,3,4 [cytosol]
Stable Identifier
R-RNO-5357900
Type
Set [CandidateSet]
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
TNFR2 non-canonical NF-kB pathway (Rattus norvegicus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF3 binds BAFFR:BAFF (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAFs bind RANK:RANKL (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Rattus norvegicus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Rattus norvegicus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Rattus norvegicus)
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
LUBAC ubiquitinates RIPK1 at K627 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Rattus norvegicus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
BIRC2,3,4 [cytosol] (Rattus norvegicus)
Participants
members
Birc2 [cytosol]
(Rattus norvegicus)
Birc3 [cytosol]
(Rattus norvegicus)
candidates
XIAP [cytosol]
(Rattus norvegicus)
Participates
as a component of
TRAF2:cIAP1,2 [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
as an output of
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
as an input of
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)
Inferred From
cIAP1,2 [cytosol]
(Homo sapiens)
BIRC2,3,4 [cytosol]
(Homo sapiens)
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