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F2 [extracellular region]
Stable Identifier
R-RNO-140598
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
thrombin light chain, P18292
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Formation of Fibrin Clot (Clotting Cascade) (Rattus norvegicus)
Common Pathway of Fibrin Clot Formation (Rattus norvegicus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Rattus norvegicus)
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Intrinsic Pathway of Fibrin Clot Formation (Rattus norvegicus)
Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)
Extracellular thrombin inactivating complexes [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
thrombin:cleaved SERPINC1 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors:IIa [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Thrombin binding to GP1b:IX:V (Rattus norvegicus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Thrombin signalling through proteinase activated receptors (PARs) (Rattus norvegicus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Complement cascade (Rattus norvegicus)
Regulation of Complement cascade (Rattus norvegicus)
Thrombin, ELANE cleave C5 (Rattus norvegicus)
Activated thrombin, (ELANE) [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Rattus norvegicus)
Thrombin proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Peptide ligand-binding receptors (Rattus norvegicus)
Proteinase-activated receptors can bind thrombin (Rattus norvegicus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P18292
Gene Names
F2
Reference Genes
ENSEMBL:ENSRNOG00000016325
ENSEMBL:ENSRNOG00055016064
ENSEMBL:ENSRNOG00060009925
ENSEMBL:ENSRNOG00065023700
UCSC:P18292 F2
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Rattus norvegicus)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [extracellular region]
F2 [extracellular region]
F2 [plasma membrane]
F2 [plasma membrane]
F2 [extracellular region]
Inferred From
thrombin light chain [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000180210
ZINC - Substances
THRB_RAT
ZINC target
P18292
PRO
P18292
ZINC - Predictions - Purchasable
THRB_RAT
RGD
61996
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