Reactome | SOS mediated nucleotide exchange of RAS (SHC)

SOS mediated nucleotide exchange of RAS (SHC)

Stable Identifier

R-RNO-112378

Type

Reaction [transition]

Species

Rattus norvegicus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

SOS mediated nucleotide exchange of RAS (SHC)

SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity. NGF-induced RAS activation via SHC-GRB2-SOS is maximal at 2 min but it is no longer detected after 5 min. Therefore, the transient activation of RAS obtained through SHC-GRB2-SOS is insufficient for the prolonged activation of ERKs found in NGF-treated cells.

Literature References

PubMed ID	Title	Journal	Year
8316835	The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Skolnik, EY, Batzer, A, Li, N, Lee, CH, Lowenstein, E, Mohammadi, M, Margolis, B, Schlessinger, J	Science	1993
9690470	The structural basis of the activation of Ras by Sos Boriack-Sjodin, PA, Margarit, SM, Bar-Sagi, D, Kuriyan, J	Nature	1998