Rasgrf1 promotes activation of HRAS

Stable Identifier
R-NUL-9617449
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Rasgrf1 promotes activation of HRAS

Recombinant rat Rasgrf1, expressed in human embryonic kidney cell line 293T and bound to endogenous human calcium-activated calmodulin (CALM1), stimulates GDP to GTP exchange on recombinant human HRAS (Farnsworth et al. 1995).

Literature References
PubMed ID Title Journal Year
7637786 Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

Farnsworth, CL, Freshney, NW, Rosen, LB, Ghosh, A, Greenberg, ME, Feig, LA

Nature 1995
Participants
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of Rasgrf1 oligomer:CALM1:4xCa2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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