Rasgrf1 promotes activation of HRAS

Stable Identifier
R-NUL-9617449
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rasgrf1 promotes activation of HRAS
Recombinant rat Rasgrf1, expressed in human embryonic kidney cell line 293T and bound to endogenous human calcium-activated calmodulin (CALM1), stimulates GDP to GTP exchange on recombinant human HRAS (Farnsworth et al. 1995).
Literature References
PubMed ID Title Journal Year
7637786 Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

Farnsworth, CL, Freshney, NW, Rosen, LB, Ghosh, A, Greenberg, ME, Feig, LA

Nature 1995
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Rasgrf1 oligomer:CALM1:4xCa2+ [plasma membrane]

Physical Entity
Rasgrf1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-08-27)
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