Reactome | NMDA-activated RASGRF1 activates RAS

NMDA-activated RASGRF1 activates RAS

Stable Identifier

R-HSA-442732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)

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Binding of RASGRF1 oligomers (Anborgh et al. 1999) to calcium-activated calmodulin (CALM1:4xCa2+) stimulates GDP to GTP exchange on RAS, resulting in RAS activation (Farnsworth et al. 1995). Binding of RASGRF1 to the GluN2B (GRIN2B, NR2B) subunit of NMDA receptors is needed for activation of RAS downstream of NDMA receptor activation (Krapivinsky et al. 2003).
Activated CaMKII can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012).

Participants

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