NMDA-activated RASGRF1 activates RAS

Stable Identifier
R-HSA-442732
Type
Reaction
Species
Homo sapiens
Compartment
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Binding of RASGRF1 oligomers (Anborgh et al. 1999) to calcium-activated calmodulin (CALM1:4xCa2+) stimulates GDP to GTP exchange on RAS, resulting in RAS activation (Farnsworth et al. 1995). Binding of RASGRF1 to the GluN2B (GRIN2B, NR2B) subunit of NMDA receptors is needed for activation of RAS downstream of NDMA receptor activation (Krapivinsky et al. 2003).
Activated CaMKII can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012).

Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane]

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