MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex

Stable Identifier
R-NUL-9005752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex
Recombinant human methyl-CpG-binding protein 2 (MECP2) mutants MECP2 P302R, MECP2 K304E, MECP2 K305R, MECP2 R306C and, based on sequence similarity, MECP2 R306H, do not bind the recombinant mouse NCoR/Smrt complex (Lyst et al. 2013).
Literature References
PubMed ID Title Journal Year
23770565 Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Lyst, MJ, Ekiert, R, Ebert, DH, Merusi, C, Nowak, J, Selfridge, J, Guy, J, Kastan, NR, Robinson, ND, de Lima Alves, F, Rappsilber, J, Greenberg, ME, Bird, A

Nat. Neurosci. 2013
Participants
Input
Normal reaction
MECP2 binds the NCoR/SMRT complex (Homo sapiens)
Functional status

Loss of function of MECP2 mutants P302R,K304E,K305R,R306C,(R306H) [nucleoplasm]

Normal Entity
Disease Entity
Status
Orthologous Events
MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)
Disease
Name Identifier Synonyms
Rett syndrome DOID:1206 Rett's disorder, cerebroatrophic hyperammonemia
Cross References
Mondo
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Christodoulou, J  (2018-08-07)
Krishnaraj, R  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-09)
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