MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex

Stable Identifier
R-NUL-9005752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex

Recombinant human methyl-CpG-binding protein 2 (MECP2) mutants MECP2 P302R, MECP2 K304E, MECP2 K305R, MECP2 R306C and, based on sequence similarity, MECP2 R306H, do not bind the recombinant mouse NCoR/Smrt complex (Lyst et al. 2013).

Literature References
PubMed ID Title Journal Year
23770565 Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Lyst, MJ, Ekiert, R, Ebert, DH, Merusi, C, Nowak, J, Selfridge, J, Guy, J, Kastan, NR, Robinson, ND, de Lima Alves, F, Rappsilber, J, Greenberg, ME, Bird, A

Nat. Neurosci. 2013
Participants
Normal reaction
Orthologous Events
Disease
Name Identifier Synonyms
Rett syndrome 1206 Rett's disorder, cerebroatrophic hyperammonemia
Authored
Reviewed
Created