MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex

Stable Identifier
R-NUL-9005752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/Smrt complex
Recombinant human methyl-CpG-binding protein 2 (MECP2) mutants MECP2 P302R, MECP2 K304E, MECP2 K305R, MECP2 R306C and, based on sequence similarity, MECP2 R306H, do not bind the recombinant mouse NCoR/Smrt complex (Lyst et al. 2013).
Literature References
PubMed ID Title Journal Year
23770565 Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

de Lima Alves, F, Kastan, NR, Guy, J, Greenberg, ME, Ekiert, R, Bird, A, Selfridge, J, Nowak, J, Ebert, DH, Robinson, ND, Merusi, C, Lyst, MJ, Rappsilber, J

Nat. Neurosci. 2013
Participants
Normal reaction
Functional status

Loss of function of MECP2 mutants P302R,K304E,K305R,R306C,(R306H) [nucleoplasm]

Status
Orthologous Events
Disease
Name Identifier Synonyms
Rett syndrome DOID:1206 Rett's disorder, cerebroatrophic hyperammonemia
Authored
Reviewed
Created
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