Gamma-secretase complex cleaves mNEXT2

Stable Identifier
R-NUL-2197556
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
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Gamma-secretase complex cleaves mNEXT2
By expressing mouse Notch2deltaE recombinant protein, which mimics the cleavage product of Adam10, NEXT2, in human embryonic kidney cell line HEK293, Saxena et al. demonstrated that the activity of the gamma-secretase complex was required for the release of Notch2 intracellular domain, NICD2, and the ensuing NICD2-mediated transcriptional response (Saxena et al. 2001).
Literature References
PubMed ID Title Journal Year
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

Saxena, MT, Schroeter, EH, Mumm, JS, Kopan, R

J Biol Chem 2001
Participants
Input
Output
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
NEXT2 is cleaved to produce NICD2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-12)
Reviewed
Haw, R  (2012-05-25)
Boyle, S  (2013-04-25)
Ilagan, MXG  (2013-04-25)
Created
Orlic-Milacic, M  (2012-04-12)
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