Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
gamma-secretase complex [plasma membrane]
Stable Identifier
R-HSA-157343
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
gamma-secretase cleaves EPHB2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NEXT1 is cleaved to produce NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NEXT2 is cleaved to produce NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NEXT3 is cleaved to produce NICD3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Noncanonical activation of NOTCH3 (Homo sapiens)
Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 PTM regulation (Homo sapiens)
TGFBR3(784-851) degradation (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24781550
Therapeutic modulation of Notch signalling--are we there yet?
Lendahl, U
,
Andersson, ER
Nat Rev Drug Discov
2014
Participants
components
APH-1 [plasma membrane]
(Homo sapiens)
NCSTN [plasma membrane]
(Homo sapiens)
Presenilin [plasma membrane]
(Homo sapiens)
PSENEN [plasma membrane]
(Homo sapiens)
This entity regulates
Positively
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
(Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1
(Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1
(Homo sapiens)
Inferred To
gamma-secretase complex [plasma membrane]
(Bos taurus)
gamma-secretase complex [plasma membrane]
(Caenorhabditis elegans)
gamma-secretase complex [plasma membrane]
(Canis familiaris)
gamma-secretase complex [plasma membrane]
(Danio rerio)
gamma-secretase complex [plasma membrane]
(Drosophila melanogaster)
gamma-secretase complex [plasma membrane]
(Gallus gallus)
gamma-secretase complex [plasma membrane]
(Mus musculus)
gamma-secretase complex [plasma membrane]
(Rattus norvegicus)
gamma-secretase complex [plasma membrane]
(Sus scrofa)
gamma-secretase complex [plasma membrane]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text