TGFBR1 is recruited to tight junction by binding Pard6a

Stable Identifier
R-NUL-2161147
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cell junction, plasma membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
TGFBR1 is recruited to tight junction by binding Pard6a
FLAG-tagged mouse Pard6a exogenously expressed in human embryonic kidney cell line, HEK293, binds HA-tagged human TGFBR1. According to studies in confluent normal murine mammary monolayers, NMuMG, exogenous human Myc-tagged TGFBR1 and exogenously expressed mouse FLAG-tagged Pard6a co-localize with endogenous ZO1 protein, a marker of tight junctions (Ozdamar et al. 2005).
Literature References
PubMed ID Title Journal Year
15761148 Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

Ozdamar, B, Bose, R, Barrios-Rodiles, M, Wang, HR, Zhang, Y, Wrana, JL

Science 2005
Participants
Input
Output
Orthologous Events
TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-08)
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