mDvl1 binds FZD7

Stable Identifier
R-NUL-1504194
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
mDvl1 binds FZD7
The PDZ domain of mDvl1 mediates a direct interaction with a conserved motif of FZD7 that is located just after the seventh transmembrane segment of the receptor. This FZD-Dvl interaction is thought to initiate recruitment of Axin-GSK3-beta to the membrane by virtue of the interaction between Axin and the DIX domain of Dvl.
Literature References
PubMed ID Title Journal Year
17234765 An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth

Fujii, N, You, L, Xu, Z, Uematsu, K, Shan, J, He, B, Mikami, I, Edmondson, LR, Neale, G, Zheng, J, Guy, RK, Jablons, DM

Cancer Res 2007
Participants
Input
Output
Orthologous Events
FZD recruits DVL to the receptor complex (Homo sapiens)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2011-08-24)
Cite Us!