FZD recruits DVL to the receptor complex

Stable Identifier
R-HSA-1504188
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DVL is recruited to the plasma membrane through a direct interaction between its PDZ domain and a conserved motif of FZD located after the seventh transmembrane region. Recruitment of DVL to the receptor complex is thought to initiate recruitment of AXIN and GSK3beta (Fujii et al, 2007; Wong et al, 2003; Zeng et al, 2008; Tauriello et al, 2012).

Literature References
PubMed ID Title Journal Year
22411803 Wnt/?-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

Tauriello, DV, Jordens, I, Kirchner, K, Slootstra, JW, Kruitwagen, T, Bouwman, BA, Noutsou, M, RĂ¼diger, SG, Schwamborn, K, Schambony, A, Maurice, MM

Proc. Natl. Acad. Sci. U.S.A. 2012
18077588 Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

Zeng, X, Huang, H, Tamai, K, Zhang, X, Harada, Y, Yokota, C, Almeida, K, Wang, J, Doble, B, Woodgett, J, Wynshaw-Boris, A, Hsieh, JC, He, X

Development 2008
17234765 An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth

Fujii, N, You, L, Xu, Z, Uematsu, K, Shan, J, He, B, Mikami, I, Edmondson, LR, Neale, G, Zheng, J, Guy, RK, Jablons, DM

Cancer Res 2007
14636582 Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

Wong, HC, Bourdelas, A, Krauss, A, Lee, HJ, Shao, Y, Wu, D, Mlodzik, M, Shi, DL, Zheng, J

Mol Cell 2003
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