Reactome | Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut

Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut

Stable Identifier

R-NUL-1250468

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

General

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Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut

Sos1 bound to exogenously expressed human GRB2 in complex with phosphorylated rat oncoprotein Erbb2mut catalyzes endogenous Ras guanyl--nucleotide exchange in mouse fibroblasts.

Literature References

PubMed ID	Title	Journal	Year
8530511	Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu Xie, Y, Pendergast, AM, Hung, MC	J Biol Chem	1995

Participants

Input

Output

Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2:Sos1:P-Erbb2mut [plasma membrane]

Physical Entity

GRB2:Sos1:P-Erbb2mut [plasma membrane] (Homo sapiens)

Activity

guanyl-nucleotide exchange factor activity (GO:0005085)

Orthologous Events

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers (Homo sapiens)

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Neckers, LM (2011-11-11)

Xu, W (2011-11-11)

Created

Orlic-Milacic, M (2011-04-21)

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