RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.

Stable Identifier
R-HSA-1250498
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
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SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR heterodimer catalyzes guanyl-nucleotide exchange on RAS, leading to activation of the MAP kinase cascade (Janes et al. 1994).

Literature References
PubMed ID Title Journal Year
7970720 Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

Janes, PW, Daly, RJ, deFazio, A, Sutherland, RL

Oncogene 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
Physical Entity
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
Activity
Ras guanyl-nucleotide exchange factor activity (0005088)
Inferred From
Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-21)