SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR heterodimer catalyzes guanyl-nucleotide exchange on RAS, leading to activation of the MAP kinase cascade (Janes et al. 1994).
Daly, RJ, deFazio, A, Janes, PW, Sutherland, RL
guanyl-nucleotide exchange factor activity of EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
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