RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.

Stable Identifier
R-HSA-1250498
Type
Reaction
Species
Homo sapiens
Compartment
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SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR heterodimer catalyzes guanyl-nucleotide exchange on RAS, leading to activation of the MAP kinase cascade (Janes et al. 1994).

Literature References
PubMed ID Title Journal Year
7970720 Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2

Daly, RJ, deFazio, A, Janes, PW, Sutherland, RL

Oncogene 1994
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]

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