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phospho-p-Y187,Y198-CHUK [cytosol]
Stable Identifier
R-MMU-9861501
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q60680
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-Y187,Y198-CHUK [cytosol] (Mus musculus)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Mus musculus)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
phospho-p-Y187,Y198-CHUK [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60680
Reference Genes
ENSEMBL:ENSMUSG00000025199
UCSC:Q60680 CHUK
Participates
as a component of
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-T23-CHUK [cytosol]
phospho-p-S176,S180-CHUK [cytosol]
CHUK [cytosol]
Inferred From
p-Y187,Y198-CHUK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 198 (in Homo sapiens)
Coordinate
198
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
PRO
Q60680
MGI
99484
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O88522
5
IKBKG [cytosol]
(R-MMU-168108)
Ub-285-IKBKG [cytosol]
(R-MMU-741397)
K63polyUb-IKBKG [cytosol]
(R-MMU-202530)
IKBKG [nucleoplasm]
(R-MMU-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-MMU-4755449)
0.85
6
UniProt:O88351
2
phospho-p-S177,S181-IKBKB [cytosol]
(R-MMU-202506)
IKBKB [cytosol]
(R-MMU-168114)
0.656
4
UniProt:P70434
3
phospho-Irf7 [nucleoplasm]
(R-MMU-450270)
phospho-Irf7 [cytosol]
(R-MMU-450318)
Irf7 [cytosol]
(R-MMU-450281)
0.524
3
UniProt:C3VPR6
2
K63polyUb-NLRC5 [cytosol]
(R-MMU-9750938)
NLRC5 [cytosol]
(R-MMU-937324)
0.524
4
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.508
2
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