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phospho-Irf7 [cytosol]
Stable Identifier
R-MMU-450318
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-S477,S479-IRF7, P70434
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Mus musculus)
p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF3-dependent IRF activation pathway (Mus musculus)
Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)
IRF3-P:IRF7-P [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)
IRF3-P:IRF7-P [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
TRAF6 mediated IRF7 activation (Mus musculus)
Dimerization of p-IRF7 (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TICAM1-dependent activation of IRF3/IRF7 (Mus musculus)
Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Mus musculus)
Dimerization of p-IRF7 (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Mus musculus)
Dimerization of p-IRF7 (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
phospho-Irf7 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70434
Gene Names
Irf7
Reference Genes
BioGPS Gene:54123 Irf7
ENSEMBL:ENSMUSG00000025498
ENSEMBL:ENSMUSG00000025498.16 Irf7
KEGG Gene (Mus musculus):54123 Irf7
Monarch:54123 Irf7
NCBI Gene:54123 Irf7
UCSC:P70434 Irf7
Reference Transcript
RefSeq:NM_016850.3 Irf7
Other Identifiers
104669_at
10569102
1417244_a_at
167512_f_at
17497813
4437602
4470552
4559202
4602439
4662289
4857391
4860777
4999934
5097240
5212479
5224713
5287634
54123
5506327
A_55_P2744251
GE37194
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0002376
GO:0002753
GO:0002819
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0010468
GO:0016064
GO:0023052
GO:0032481
GO:0032727
GO:0032728
GO:0034124
GO:0034127
GO:0043226
GO:0045087
GO:0045088
GO:0045893
GO:0045944
GO:0051607
GO:0060337
GO:0060340
GO:0098542
GO:0140110
GO:1990837
ILMN_1227573
U73037_s_at
mMC020732
Participates
as an input of
Dimerization of p-IRF7 (Mus musculus)
as a member of
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
as a component of
IRF3-P:IRF7-P [cytosol] (Mus musculus)
p-2S-IRF7:p-2S-IRF7 [cytosol] (Mus musculus)
Other forms of this molecule
phospho-Irf7 [nucleoplasm]
Irf7 [cytosol]
Inferred From
p-S477,S479-IRF7 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 477 (in Homo sapiens)
Coordinate
477
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 479 (in Homo sapiens)
Coordinate
479
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_058546.1
Ensembl
ENSMUSP00000026571
,
ENSMUST00000026571
,
ENSMUSG00000025498
PRO
P70434
MGI
1859212
PDB
3QU3
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60680
3
phospho-p-T23-CHUK [cytosol]
(R-MMU-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-MMU-177667)
CHUK [cytosol]
(R-MMU-168104)
0.524
3
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