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TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]
Stable Identifier
R-MMU-9793672
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
OPTN [cytosol]
(Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane]
(Mus musculus)
Participates
as an input of
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
as a component of
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
as an output of
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
This entity regulates
Negatively
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
(Mus musculus)
Inferred From
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]
(Homo sapiens)
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