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OPTN [cytosol]
Stable Identifier
R-MMU-9687907
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q8K3K8
Locations in the PathwayBrowser
Expand all
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
Selective autophagy (Mus musculus)
Mitophagy (Mus musculus)
PINK1-PRKN Mediated Mitophagy (Mus musculus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Mus musculus)
OPTN [cytosol] (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
OPTN [cytosol] (Mus musculus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
OPTN [cytosol] (Mus musculus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
p-S-TBK1 phosphorylates OPTN (Mus musculus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Mus musculus)
OPTN binds TBK1 within the activated TLR4 complex (Mus musculus)
OPTN [cytosol] (Mus musculus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
TBK1 is phosphorylated within the activated TLR4 complex (Mus musculus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
OPTN binds CASP8 (Mus musculus)
OPTN [cytosol] (Mus musculus)
OPTN:CASP8 [cytosol] (Mus musculus)
OPTN [cytosol] (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
OPTN [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8K3K8
Reference Genes
BioGPS Gene:71648
ENSEMBL:ENSMUSG00000026672
KEGG:mmu:71648
Monarch:71648
NCBI Gene:71648
UCSC:Q8K3K8
Reference Transcript
RefSeq:XM_006497547.3
RefSeq:XM_006497546.1
RefSeq:XM_011238987.2
RefSeq:NM_181848.4
Other Identifiers
10479833
1429778_at
1435679_at
17381330
4306663
4364343
4370525
4465040
4526901
4538170
4593785
4810504
4816949
4846737
4928894
5008648
5058736
5193931
5248735
5275674
5287869
5315306
5384905
5397210
5404955
5440040
5501041
5566971
71648
A_51_P245485
A_66_P119801
GE39929
GO:0001155
GO:0001819
GO:0001920
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005768
GO:0005773
GO:0005776
GO:0005794
GO:0005802
GO:0005829
GO:0006914
GO:0007030
GO:0008104
GO:0008284
GO:0008285
GO:0010508
GO:0010628
GO:0016192
GO:0030424
GO:0030674
GO:0031410
GO:0031593
GO:0034067
GO:0034620
GO:0042802
GO:0043001
GO:0043025
GO:0043122
GO:0043124
GO:0043130
GO:0043226
GO:0043524
GO:0043525
GO:0045087
GO:0046872
GO:0048471
GO:0050829
GO:0055037
GO:0060090
GO:0061734
GO:0070530
GO:0072659
GO:0090161
GO:0098542
GO:1904417
GO:2000179
ILMN_2676606
ILMN_2907370
mMC009497
Participates
as an input of
OPTN binds CASP8 (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
OPTN binds TBK1 within the activated TLR4 complex (Mus musculus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Mus musculus)
as a component of
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
OPTN:CASP8 [cytosol] (Mus musculus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Mus musculus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Mus musculus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Mus musculus)
Other forms of this molecule
OPTN [recycling endosome membrane]
OPTN [Golgi membrane]
phospho-p-S177-OPTN [nucleoplasm]
phospho-p-S177-OPTN [cytosol]
phospho-p-S177,S473,S513-OPTN [cytosol]
Inferred From
OPTN [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006497609.1
,
NP_862896.1
,
XP_006497610.1
,
XP_011237289.1
ENSEMBL
ENSMUSP00000027986
,
ENSMUST00000027986
,
ENSMUSP00000110648
,
ENSMUST00000114996
PRO
Q8K3K8
MGI
1918898
PDB
5WQ4
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