Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Stable Identifier
R-MMU-9763903
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
After an initial wave of phosphorylation of Csf1r, the stable Grb2:Sos1 complex transiently binds phospho-Csf1r (Lioubin et al. 1994, Xiong et al 2011). Grb2 has been shown to bind phosphotyrosine-697 (van der Geer and Hunter 1993). However the phosphorylation status of tyrosine-697 at this juncture has not been assayed.
Literature References
PubMed ID Title Journal Year
10025673 CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

Wang, Y, Yeung, YG, Stanley, ER

J. Cell. Biochem. 1999
7520523 Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells

Lioubin, MN, Myles, GM, Carlberg, K, Bowtell, D, Rohrschneider, LR

Mol. Cell. Biol. 1994
Participants
Input
Output
Orthologous Events
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)
Authored
May, B  (2022-02-06)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2022-02-07)
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