Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Stable Identifier
R-MMU-9763903
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
After an initial wave of phosphorylation of Csf1r, the stable Grb2:Sos1 complex transiently binds phospho-Csf1r (Lioubin et al. 1994, Xiong et al 2011). Grb2 has been shown to bind phosphotyrosine-697 (van der Geer and Hunter 1993). However the phosphorylation status of tyrosine-697 at this juncture has not been assayed.
Literature References
PubMed ID Title Journal Year
10025673 CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

Stanley, ER, Yeung, YG, Wang, Y

J. Cell. Biochem. 1999
7520523 Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells

Carlberg, K, Myles, GM, Rohrschneider, LR, Lioubin, MN, Bowtell, D

Mol. Cell. Biol. 1994
Participants
Input
Output
Orthologous Events
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)
Authored
May, B  (2022-02-06)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2022-02-07)
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