Expression of Snai1 during gastrulation

Stable Identifier
R-MMU-9756452
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Snai1 during gastrulation
The Snail1 (Snai1) gene is transcribed to yield mRNA and the mRNA is translated to yield Snai1 protein. Transcription of Snai1 is activated by Eomes and Tbxt (Tosic et al. 2019) and by Fgf signaling via Fgfr1 (Ciruna and Rossant 2001).
Literature References
PubMed ID Title Journal Year
31792383 Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state

Tosic, J, Kim, GJ, Pavlovic, M, Schröder, CM, Mersiowsky, SL, Barg, M, Hofherr, A, Probst, S, Köttgen, M, Hein, L, Arnold, SJ

Nat Cell Biol 2019
11703922 FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak

Ciruna, B, Rossant, J

Dev Cell 2001
Participants
Input
Output
This event is regulated
Positively by
Regulator
Eomes:Tbxt:Snai1 gene [nucleoplasm] (Mus musculus)
Regulator
Basic fibroblast growth factor receptor 1 [plasma membrane] (Mus musculus)
Orthologous Events
Expression of SNAI1 during gastrulation (Homo sapiens)
Authored
May, B  (2021-10-10)
Reviewed
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Created
May, B  (2021-10-14)
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