Reactome | Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13

Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13

Stable Identifier

R-MMU-9724864

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13

The binding of ligand to the umami receptor (Tas1r1:Tas1r3) or sweet receptor (Tas1r2:Tas1r3) causes a conformational change in the receptor that is transmitted to the associated gustducin G-protein heterotrimer (Gnat33:Gnb1,3:Gng13) and causes the alpha subunit, Gnat3 (gustducin), to exchange GDP for GTP (Wong et al. 1996). Gustducin alpha (Gnat3) and Ggamma 13 (Gng13) colocalize with Tas1r1:Tas1r3 bitter receptors and are required to activate downstream IP3 signaling (Huang et al. 1999, Caicedo et al. 2003). Loss of Gnat3 function causes loss of responsiveness to sweet tastants (Ruiz-Avila et al. 2001) and bitter tastants (Caicedo et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
8657284	Transduction of bitter and sweet taste by gustducin Wong, GT, Gannon, KS, Margolskee, RF	Nature	1996
11447270	Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin Ruiz-Avila, L, Wong, GT, Damak, S, Margolskee, RF	Proc Natl Acad Sci U S A	2001
10570481	Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium Huang, L, Shanker, YG, Dubauskaite, J, Zheng, JZ, Yan, W, Rosenzweig, S, Spielman, AI, Max, M, Margolskee, RF	Nat Neurosci	1999
14586025	Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli Caicedo, A, Pereira, E, Margolskee, RF, Roper, SD	J. Neurosci.	2003