GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13

Stable Identifier
R-HSA-9728697
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13
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Binding of a sweet tastant to the sweet taste receptor (TAS1R2:TAS1R3) causes a change in conformation that then causes the Galpha subunit (GNAT3, gustducin) of the associated heterotrimeric G protein complex to exchange GDP for GTP (Sainz et al. 2007). The TAS1R2 subunit is primarily responsible for activating guanylate nucleotide exchange by GNAT3 (Sainz et al. 2007).
Literature References
PubMed ID Title Journal Year
17506496 The G-protein coupling properties of the human sweet and amino acid taste receptors

Gutierrez, JC, LopezJimenez, ND, Sainz, E, Battey, JF, Cavenagh, MM, Northup, JK, Sullivan, SL

Dev Neurobiol 2007
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Output
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as an event of
Inferred From
Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13 (Mus musculus)
Authored
May, B  (2021-04-19)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-04-21)
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