GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13

Stable Identifier
R-HSA-9728697
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of a sweet tastant to the sweet taste receptor (TAS1R2:TAS1R3) causes a change in conformation that then causes the Galpha subunit (GNAT3, gustducin) of the associated heterotrimeric G protein complex to exchange GDP for GTP (Sainz et al. 2007). The TAS1R2 subunit is primarily responsible for activating guanylate nucleotide exchange by GNAT3 (Sainz et al. 2007).

Literature References
PubMed ID Title Journal Year
17506496 The G-protein coupling properties of the human sweet and amino acid taste receptors

Sainz, E, Cavenagh, MM, LopezJimenez, ND, Gutierrez, JC, Battey, JF, Northup, JK, Sullivan, SL

Dev Neurobiol 2007
Participants
Participates
Inferred From
Authored
Reviewed
Created
Cite Us!