Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Stable Identifier
R-MMU-9682572
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
In response to the activation of Csf1r by Csf1, Sos1 bound to the activated Csf1r via Grb2 promotes Ras to exchange of GDP for GTP (Büscher et al. 1995, Lee and States 2000, Yu et al. 2012). Activated Ras promotes cell proliferation via ERK. Myeloid cells contain the Kras isoform of Ras.
Literature References
PubMed ID Title Journal Year
22375015 Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807

Yu, W, Chen, J, Xiong, Y, Pixley, FJ, Yeung, YG, Stanley, ER

J. Biol. Chem. 2012
10958675 Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors

Lee, AW, States, DJ

Mol. Cell. Biol. 2000
7799956 Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages

Büscher, D, Hipskind, RA, Krautwald, S, Reimann, T, Baccarini, M

Mol. Cell. Biol. 1995
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Csf1 dimer:p-Y559-Csf1r dimer:Grb2:Sos1 [plasma membrane]

Physical Entity
Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1:Grb2:Sos1 [plasma membrane] (Mus musculus)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
Authored
May, B  (2020-04-08)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-04-11)
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