Reactome | Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Stable Identifier

R-MMU-9682158

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

In response to Csf1, Plcg2 (phospholipase C gamma2) associates with Csf1r, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Xu et al. 1993, Bourgin-Hierle et al. 2008). Plcg2 activates pathways that enhance differentiation of macrophages (Bourette et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8441394	Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1 Tessner, TG, Xu, XX, Rock, CO, Jackowski, S	Mol. Cell. Biol.	1993
17972959	Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2 Thérier, J, Mouchiroud, G, Grasset, MF, Bourgin-Hierle, C, Gobert-Gosse, S	Leukemia	2008
9312046	Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling Myles, GM, Rohrschneider, LR, Choi, JL, Bourette, RP	EMBO J.	1997

Participants

Input

Output

Catalyst Activity

phosphatidylcholine phospholipase C activity of Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane]

Physical Entity

Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane] (Mus musculus)

Activity

phosphatidylcholine phospholipase C activity (GO:0034480)

Orthologous Events

CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)

Authored

May, B (2020-04-04)

Reviewed

Stanley, ER (2022-10-06)

Created

May, B (2020-04-08)