Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Stable Identifier
R-MMU-9682158
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
In response to Csf1, Plcg2 (phospholipase C gamma2) associates with Csf1r, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Xu et al. 1993, Bourgin-Hierle et al. 2008). Plcg2 activates pathways that enhance differentiation of macrophages (Bourette et al. 1997).
Participants
Catalyst Activity

phosphatidylcholine phospholipase C activity of Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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