CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine

Stable Identifier
Reaction [transition]
Homo sapiens
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In response to CSF1, PLCG2 (phospholipase C gamma2) associates with CSF1R, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Imamura et al. 1990, Nakamura et al. 1992, Obba et al. 2015, also inferred from mouse homologs). PLCG2 activates pathways that enhance differentiation of macrophages (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
26029847 The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

Jacquel, A, Pfeifer, A, Luciano, F, Droin, N, Cluzeau, T, Robaye, B, Boyer, L, Hamouda, MA, Solary, E, Gonçalvès, D, Robert, G, Foretz, M, Hizir, Z, Marchetti, S, Viollet, B, Selimoglu-Buet, D, Auberger, P, Legros, L, Michel, G, Rocchi, S, Obba, S, Cerezo, M

Autophagy 2015
2196173 Colony-stimulating factor 1 activates protein kinase C in human monocytes

Imamura, K, Dianoux, A, Nakamura, T, Kufe, D

EMBO J. 1990
1334462 Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2

Nakamura, T, Kharbanda, S, Kufe, D, Lin, LL, Knopf, J

EMBO J. 1992
Catalyst Activity

phosphatidylcholine phospholipase C activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]

Inferred From
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