CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine

Stable Identifier
R-HSA-9680388
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine
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In response to CSF1, PLCG2 (phospholipase C gamma2) associates with CSF1R, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Imamura et al. 1990, Nakamura et al. 1992, Obba et al. 2015, also inferred from mouse homologs). PLCG2 activates pathways that enhance differentiation of macrophages (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
26029847 The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

Jacquel, A, Pfeifer, A, Luciano, F, Droin, N, Cluzeau, T, Robaye, B, Boyer, L, Hamouda, MA, Solary, E, Gonçalvès, D, Robert, G, Foretz, M, Hizir, Z, Marchetti, S, Viollet, B, Selimoglu-Buet, D, Auberger, P, Legros, L, Michel, G, Rocchi, S, Obba, S, Cerezo, M

Autophagy 2015
2196173 Colony-stimulating factor 1 activates protein kinase C in human monocytes

Imamura, K, Dianoux, A, Nakamura, T, Kufe, D

EMBO J. 1990
1334462 Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2

Nakamura, T, Kharbanda, S, Kufe, D, Lin, LL, Knopf, J

EMBO J. 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylcholine phospholipase C activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]

Physical Entity
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
Activity
phosphatidylcholine phospholipase C activity (GO:0034480)
Inferred From
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol (Mus musculus)
Authored
May, B  (2020-03-27)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-03-27)
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