Csf1 dimer binds Csf1r

Stable Identifier
R-MMU-9680703
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf1 dimer binds Csf1r
Csf1r binds with its extracellular D2 and D3 domains to Csf1 (Chen et al. 2008) or Il-34 (Chihara et al. 2010). One Csf1 subunit binds to one Csf1r molecule, the second Csf1 subunit binds another Csf1r molecule, resulting in dimerization of Csf1r by interaction of the D4 and D5 domains of Csf1r (Chen et al. 2008).
Literature References
PubMed ID Title Journal Year
20489731 IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

Chihara, T, Suzu, S, Hassan, R, Chutiwitoonchai, N, Hiyoshi, M, Motoyoshi, K, Kimura, F, Okada, S

Cell Death Differ. 2010
19017797 Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases

Chen, X, Liu, H, Focia, PJ, Shim, AH, He, X

Proc Natl Acad Sci U S A 2008
Participants
Input
Output
Orthologous Events
CSF1 dimer binds CSF1R or IL34 (Homo sapiens)
Authored
May, B  (2020-03-28)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-03-28)
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