CSF1 dimer binds CSF1R or IL34

Stable Identifier
R-HSA-389156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CSF1 dimer binds CSF1R or IL34
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Colony-stimulating factor 1 receptor (CSF1R, CSF-1R) is a protein tyrosine kinase transmembrane receptor for colony-stimulating factor-1 (CSF1, macrophage CSF, M-CSF) and for interleukin-34 (IL-34) (Wang et al. 1993, Lin et al. 2008, Chihara et al. 2010, Ma et al. 2012, Felix et al. 2015). Responses of CSF1R to CSF1 and IL34 are qualitatively similar but quantitatively different (Chihara et al. 2010). CSF1R is a transmembrane glycoprotein and contains five extracellular ligand binding immunoglobulin-like domains, a single transmembrane segment, and a split intracellular kinase domain. CSF1 is a disulfide linked homodimer and either expressed as a transmembrane molecule or proteolytically processed to produce soluble glycoprotein or proteoglycan forms (Stanley and Chitu, 2014). IL-34 is a non-covalently linked homodimer that is secreted (Lin et al. 2008).
CSF1R binds with its extracellular D2 and D3 domains to CSF1 or IL-34. One CSF1 subunit binds to one CSF1R molecule, the second CSF1 subunit binds another CSF1R molecule, resulting in dimerization of CSF1R through the interaction of its D4 and D5 domains (Wang et al. 1993, Chihara et al. 2010, Ma et al. 2012, Felix et al. 2012).
Literature References
PubMed ID Title Journal Year
20489731 IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

Hassan, R, Kimura, F, Suzu, S, Chutiwitoonchai, N, Motoyoshi, K, Hiyoshi, M, Okada, S, Chihara, T

Cell Death Differ. 2010
22483114 Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R

Mukhyala, K, Chen, Y, Ma, X, Martin, F, Wu, Y, Lin, WY, Starovasnik, MA, Stawicki, S, Bazan, JF

Structure 2012
26235028 Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1

Verstraete, K, Felix, J, Callewaert, N, Elegheert, J, Meuris, L, Savvides, SN, De Munck, S

Structure 2015
18467591 Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

Leo, C, Halenbeck, R, Linnemann, T, Doberstein, SK, Lin, H, Williams, LT, Qin, M, Wong, J, Wu, G, Behrens, D, Huang, M, Hollenbaugh, D, Hestir, K, Chu, K, Lee, E, Zhou, A, Bosch, E

Science 2008
8355686 Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain

Myles, GM, Brandt, CS, Wang, ZE, Rohrschneider, L, Lioubin, MN

Mol Cell Biol 1993
24890514 CSF-1 receptor signaling in myeloid cells

Stanley, ER, Chitu, V

Cold Spring Harb Perspect Biol 2014
Participants
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Output
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as an event of
Inferred From
Csf1 dimer binds Csf1r (Mus musculus)
Authored
May, B  (2020-03-14)
Garapati, P V  (2008-12-22)
Reviewed
Stanley, ER  (2022-10-06)
Created
Garapati, P V  (2008-12-22)
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