Translation of Ppp1r15a

Stable Identifier
R-MMU-9653773
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translation of Ppp1r15a
The Ppp1r15a (Gadd34) mRNA is translated to yield Ppp1r15a protein (Young et al. 2015, Zhang et al. 2019) which then associates with the cytosolic faces of the endoplasmic reticulum membrane and the mitochondrial outer membrane. The Ppp1r15a mRNA contains 2 upstream ORFs (uORFs) that limit translation of the downstream Ppp1r15a coding region (Young et al. 2015). During certain stresses, Eif2s1 (Eif2-alpha) is phosphorylated, causing a reduction in initiation at the uORFs and increased translation of the Ppp1r15a coding region (Young et al. 2015, Zhang et al. 2019).
Literature References
PubMed ID Title Journal Year
26446796 Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response

Young, SK, Willy, JA, Wu, C, Sachs, MS, Wek, RC

J. Biol. Chem. 2015
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Zhang, S, Macias-Garcia, A, Ulirsch, JC, Velazquez, J, Butty, VL, Levine, SS, Sankaran, VG, Chen, JJ

Elife 2019
Participants
Input
Output
This event is regulated
Positively by
Regulator
p-S52-Eif2s1:Eif2s2:Eif2s3 [cytosol] (Mus musculus)
Orthologous Events
Translation of PPP1R15A (Homo sapiens)
Authored
May, B  (2019-07-15)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-15)
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