Eif2ak4 dimer autophosphorylates

Stable Identifier
R-MMU-9633741
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eif2ak4 dimer autophosphorylates
After binding uncharged tRNA, the Eif2ak4 (Gcn2) dimer trans-autophosphorylates on threonine-898, resulting in activation of the kinase domain of Eif2ak4 (Harding et al. 2000, Deng et al. 2002, Cambiaghi et al. 2014, and inferred from yeast homologs).
Literature References
PubMed ID Title Journal Year
24333428 Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Cambiaghi, TD, Pereira, CM, Shanmugam, R, Bolech, M, Wek, RC, Sattlegger, E, Castilho, BA

Biochem. Biophys. Res. Commun. 2014
11106749 Regulated translation initiation controls stress-induced gene expression in mammalian cells

Harding, HP, Novoa, I, Zhang, Y, Zeng, H, Wek, R, Schapira, M, Ron, D

Mol. Cell 2000
12176355 Activation of GCN2 in UV-irradiated cells inhibits translation

Deng, J, Harding, HP, Raught, B, Gingras, AC, Berlanga, JJ, Scheuner, D, Kaufman, RJ, Ron, D, Sonenberg, N

Curr. Biol. 2002
Participants
Input
Output
Inferred From
GCN2 dimer autophosphorylates (Saccharomyces cerevisiae)
Orthologous Events
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
Authored
May, B  (2018-12-29)
Reviewed
Bruhat, A  (2019-09-15)
Staschke, KA  (2019-11-20)
Created
May, B  (2018-12-31)
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