Eif2ak4 dimer autophosphorylates

Stable Identifier
R-MMU-9633741
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Eif2ak4 dimer autophosphorylates

After binding uncharged tRNA, the Eif2ak4 (Gcn2) dimer trans-autophosphorylates on threonine-898, resulting in activation of the kinase domain of Eif2ak4 (Harding et al. 2000, Deng et al. 2002, Cambiaghi et al. 2014, and inferred from yeast homologs).

Literature References
PubMed ID Title Journal Year
11106749 Regulated translation initiation controls stress-induced gene expression in mammalian cells

Harding, HP, Novoa, I, Zhang, Y, Zeng, H, Wek, R, Schapira, M, Ron, D

Mol. Cell 2000
24333428 Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Cambiaghi, TD, Pereira, CM, Shanmugam, R, Bolech, M, Wek, RC, Sattlegger, E, Castilho, BA

Biochem. Biophys. Res. Commun. 2014
12176355 Activation of GCN2 in UV-irradiated cells inhibits translation

Deng, J, Harding, HP, Raught, B, Gingras, AC, Berlanga, JJ, Scheuner, D, Kaufman, RJ, Ron, D, Sonenberg, N

Curr. Biol. 2002
Participants
Inferred From
Orthologous Events
Authored
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