GCN2 dimer autophosphorylates

Stable Identifier
R-SCE-9633750
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
GCN2 dimer autophosphorylates

After binding uncharged tRNA, the GCN2 dimer trans-autophosphorylates threonine-882 and threonine-887, resulting in activation of the kinase domain of GCN2 (Romano et al. 1998).

Literature References
PubMed ID Title Journal Year
9528799 Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

Romano, PR, Garcia-Barrio, MT, Zhang, X, Wang, Q, Taylor, DR, Zhang, F, Herring, C, Mathews, MB, Qin, J, Hinnebusch, AG

Mol. Cell. Biol. 1998
Participants
Catalyst Activity

protein serine/threonine kinase activity of tRNA:GCN2:GCN1:80S ribosome:mRNA [cytosol]

Orthologous Events
Authored
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