EIF2AK4 (GCN2) dimer autophosphorylates

Stable Identifier
R-HSA-9633742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After binding uncharged tRNA, the EIF2AK4 (GCN2) dimer trans-autophosphorylates on threonine-899, resulting in activation of the kinase domain of EIF2AK4 (Harding et al. 2000, Deng et al. 2002, Cambiaghi et al. 2014, and inferred from mouse homologs and yeast homologs).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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