EIF2AK4 (GCN2) dimer autophosphorylates

Stable Identifier
R-HSA-9633742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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EIF2AK4 (GCN2) dimer autophosphorylates
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After binding uncharged tRNA, the EIF2AK4 (GCN2) dimer trans-autophosphorylates on threonine-899, resulting in activation of the kinase domain of EIF2AK4 (Harding et al. 2000, Deng et al. 2002, Cambiaghi et al. 2014, and inferred from mouse homologs and yeast homologs).
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol]

Physical Entity
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Eif2ak4 dimer autophosphorylates (Mus musculus)
GCN2 dimer autophosphorylates (Saccharomyces cerevisiae)
Authored
May, B  (2018-12-29)
Reviewed
Staschke, KA  (2019-11-20)
Bruhat, A  (2019-09-15)
Created
May, B  (2018-12-31)
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