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EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-MMU-9624425
Type
Complex
Species
Mus musculus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
PTK2 autophosphorylates downstream of EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
PTK2 binds activated EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
EGFR autophosphorylation (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGFR downregulation (Mus musculus)
Binding of CBL to EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
CBL ubiquitinates Sprouty (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Localization of CBL:GRB2 to the membrane (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Phosphorylation of CBL (EGFR:CBL) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGFR interacts with phospholipase C-gamma (Mus musculus)
Active PLC-gamma1 dissociates from EGFR (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
GAB1 signalosome (Mus musculus)
Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Dephosphorylation of PAG by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
GAB1 phosphorylation by EGFR kinase (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Sustained activation of SRC kinase by SHP2 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
GRB2 events in EGFR signaling (Mus musculus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
Phosphorylation of EGFR by SRC kinase (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SHC1 events in EGFR signaling (Mus musculus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Mus musculus)
x 2
phospho-p-6Y-EGFR [plasma membrane]
(Mus musculus)
Participates
as an input of
PTK2 binds activated EGFR (Mus musculus)
Binding of CBL to EGFR (Mus musculus)
Localization of CBL:GRB2 to the membrane (Mus musculus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)
GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)
as a component of
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
as an output of
Active PLC-gamma1 dissociates from EGFR (Mus musculus)
EGFR autophosphorylation (Mus musculus)
Phosphorylation of EGFR by SRC kinase (Mus musculus)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
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