Creb, Srf, and Mef2d bind the ARC gene

Stable Identifier
R-MMU-9620391
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Creb, Srf, and Mef2d bind the ARC gene
Studies in mouse identified a Synaptic Activity Response Element (SARE) ~7kb upstream of the transcription start site that promotes ARC gene transcription under stimulatory synaptic conditions. The SARE contains at least 3 conserved binding regions with consensus sites for Mef2d, Srf and Creb, and EMSA and ChIP confirm binding to these sites (Kawashima et al, 2009).
Literature References
PubMed ID Title Journal Year
19116276 Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

Kawashima, T, Okuno, H, Nonaka, M, Adachi-Morishima, A, Kyo, N, Okamura, M, Takemoto-Kimura, S, Worley, PF, Bito, H

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Input
Output
Orthologous Events
p-S133 CREB1, MEF2D and SRF bind the ARC gene (Homo sapiens)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-22)
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