Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1

Stable Identifier
R-MMU-9607226
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1
Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with Growth factor receptor-bound protein 2 (Grb2), which then recruits Grb2-associated-binding protein 2 (Gab2). Ultimately, Gab2 is phosphorylated and recruits Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1). The p85 alpha subunit of Pik3 is known to bind with Gab2 (Zhang et al. 2000, Masson et al. 2009).
Literature References
PubMed ID Title Journal Year
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L

Br. J. Haematol. 2009
11027663 Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

Zhang, S, Broxmeyer, HE

Biochem. Biophys. Res. Commun. 2000
Participants
Input
Output
Orthologous Events
FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)
FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)
Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 (Homo sapiens)
Authored
Varusai, TM  (2019-01-14)
Reviewed
Traer, E  (2019-05-03)
Joshi, S  (2019-05-21)
Created
Varusai, TM  (2018-05-01)
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