FLT3 fusions signal through the PI3K/AKT pathway as assessed by increased phosphorylation of AKT downstream of activated fusions (Grand et al, 2007; Vu et al, 2009; Troadec et al, 20017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand, 2019). Recruitment and activation of PI3K is likely mediated by GRB2-GAB2 as is the case for the wild-type receptor, although this has not been directly demonstrated (Zhang et al, 1999; Zhang et al, 2000; Masson et al, 2009).
Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L
Kazi, JU, Rönnstrand, L
Petit, B, Dobbelstein, S, Chauzeix, J, Touati, M, Gachard, N, Faumont, N, Bertrand, P, Troadec, E, Trimoreau, F, Bordessoule, D, Bastard, C, Feuillard, J
Xinh, PT, Vu, HA, Kano, Y, Tokunaga, K, Sato, Y
Zhang, S, Broxmeyer, HE
Grand, FH, Zhang, L, Russell, NH, Cross, NC, Chase, A, Iqbal, S
Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A
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