FLT3 ITD mutants signal through the PI3K/AKT pathway in a GRB2-GAB2-dependent manner. As is the case for the wild-type receptor, FLT3 ITD-associated GAB2 is phosphorylated and recruits the p85 regulatory subunit of PI3K to the activated receptor (Masson et al, 2009; Zhang et al, 1999; Zhang et al, 2000). Other FLT3-interacting adaptor proteins have also been shown to bind to p85 and may additionally contribute to PI3K/AKT signaling downstream of FLT3; these alternate mechanisms are not shown in this pathway (reviewed in Kazi and Ronnstrand, 2019).
Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L
Kazi, JU, Rönnstrand, L
Zhang, S, Broxmeyer, HE
Gain of function of p-6Y FLT3 mutant dimers:GRB2:p-Y GAB2 [plasma membrane]
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