FLT3 mutants recruit PIK3R1 through phosphorylated GAB2

Stable Identifier
R-HSA-9698179
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FLT3 ITD mutants signal through the PI3K/AKT pathway in a GRB2-GAB2-dependent manner. As is the case for the wild-type receptor, FLT3 ITD-associated GAB2 is phosphorylated and recruits the p85 regulatory subunit of PI3K to the activated receptor (Masson et al, 2009; Zhang et al, 1999; Zhang et al, 2000). Other FLT3-interacting adaptor proteins have also been shown to bind to p85 and may additionally contribute to PI3K/AKT signaling downstream of FLT3; these alternate mechanisms are not shown in this pathway (reviewed in Kazi and Ronnstrand, 2019).

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Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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