Reactome | Spectrin alpha chain, brain [cytosol]

Spectrin alpha chain, brain [cytosol]

Stable Identifier

R-MMU-681570

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Sptan1, SPTA2_MOUSE, Sptan1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        COPI vesicle uncoating (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
      - ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
      - COPI vesicle uncoating (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spectrin alpha chain, brain [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P16546 Sptan1

Gene Names

Sptan1, Spna2, Spta2

Chain

chain:1-2472

Reference Genes

UCSC:P16546 Sptan1

Other Identifiers

103345_at

10470834

135064_at

1427888_a_at

1427889_at

17369001

20740

4306466

4314137

4332999

4345139

4355995

4375411

4376747

4388248

4407629

4408698

4415288

4415803

4417121

4432451

4438833

4476887

4493286

4511186

4524249

4528344

4540548

4548150

4556169

4559308

4582872

4604410

4620393

4625479

4629185

4669397

4670599

4693872

4717068

4721472

4727155

4734879

4746221

4751307

4769672

4781784

4802926

4816089

4832113

4834848

4880606

4898643

4906763

4910228

4941250

4945431

4951489

4991804

4995815

4999261

5001726

5018344

5051128

5080169

5084491

5111226

5192278

5193320

5197888

5227401

5258220

5271726

5284455

5341340

5344992

5377785

5402680

5419733

5445614

5453936

5569339

A_51_P125866

A_51_P140000

A_51_P476783

A_52_P339496

A_55_P2072980

A_55_P2072985

A_55_P2720233

GE1566290

GE39579

GO:0003779

GO:0005509

GO:0005515

GO:0005516

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005916

GO:0005938

GO:0007010

GO:0008092

GO:0015629

GO:0015630

GO:0016020

GO:0016328

GO:0030018

GO:0030036

GO:0030054

GO:0030507

GO:0030863

GO:0030864

GO:0032437

GO:0032991

GO:0033010

GO:0033270

GO:0042995

GO:0043209

GO:0043226

GO:0043231

GO:0044877

GO:0046872

GO:0051015

GO:0051693

GO:0098794

GO:0098978

ILMN_1234438

ILMN_1235010

ILMN_1260571

ILMN_2455928

ILMN_2618634

Msa.38342.0_s_at

mMC020972

mMC023859

Participates

as a candidate of

as a component of

as an input of

Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)

as a member of

Spectrin alpha chain [cytosol] (Mus musculus)

Other forms of this molecule

SPTAN1 [tertiary granule lumen]

SPTAN1 [extracellular region]

SPTAN1 [specific granule lumen]

SPTAN1(1186-2472) [cytosol]

SPTAN1(1-1185) [cytosol]

Inferred From

SPTAN1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUST00000046257, ENSMUSP00000047792, ENSMUST00000095083, ENSMUSP00000092697

PRO

P16546

GlyGen

P16546

MGI

98386

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q4ACU6	1	Shank3 [cytosol] (R-MMU-6794277)	0.527	2
UniProt:Q5I1X5	1	Ppp1r13l [nucleoplasm] (R-MMU-6799738)	0.499	2

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