Reactome | Shank3 [cytosol]

Shank3 [cytosol]

Stable Identifier

R-MMU-6794277

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SHANK3, Q4ACU6

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Protein-protein interactions at synapses (Mus musculus)
  - Neurexins and neuroligins (Mus musculus)
    - ABP1 binds SHANK proteins (Mus musculus)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Mus musculus)
        
        SHANK1,2,3 [cytosol] (Mus musculus)
        
        Shank3 [cytosol] (Mus musculus)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Mus musculus)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Mus musculus)
        
        SHANK1,2,3 [cytosol] (Mus musculus)
        
        Shank3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q4ACU6

Gene Names

Shank3

Reference Genes

BioGPS Gene:58234 Shank3

ENSEMBL:ENSMUSG00000022623

KEGG Gene (Mus musculus):58234 Shank3

Monarch:58234 Shank3

NCBI Gene:58234 Shank3

UCSC:Q4ACU6 Shank3

Reference Transcript

RefSeq:NM_021423.3 Shank3

Other Identifiers

10426261

105820_at

105954_at

1419137_at

17314190

4375493

4412944

4428518

4554535

4576763

4606778

4647349

4657132

4684471

4812454

4825047

4837747

4877754

4897702

4965349

4965605

4987548

5081072

5109679

5140466

5233661

5235327

5249382

5254971

5370664

5565681

58234

A_51_P115626

A_55_P2089858

GE37946

GO:0000165

GO:0000902

GO:0001838

GO:0003674

GO:0003779

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005929

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007165

GO:0007267

GO:0007416

GO:0007611

GO:0007612

GO:0007613

GO:0007626

GO:0008022

GO:0008092

GO:0008150

GO:0008270

GO:0008328

GO:0009790

GO:0014069

GO:0017124

GO:0021773

GO:0022607

GO:0030054

GO:0030154

GO:0030160

GO:0030534

GO:0030674

GO:0031234

GO:0032232

GO:0032991

GO:0034330

GO:0035176

GO:0035255

GO:0035640

GO:0035641

GO:0040007

GO:0040011

GO:0042297

GO:0042592

GO:0042802

GO:0042995

GO:0043005

GO:0043167

GO:0043197

GO:0043226

GO:0043621

GO:0044309

GO:0044877

GO:0045202

GO:0045211

GO:0045794

GO:0048167

GO:0048170

GO:0048646

GO:0048854

GO:0048856

GO:0050807

GO:0050877

GO:0050885

GO:0051124

GO:0051835

GO:0051968

GO:0055085

GO:0060076

GO:0060170

GO:0060291

GO:0060292

GO:0060997

GO:0060999

GO:0061001

GO:0061024

GO:0071625

GO:0097107

GO:0097110

GO:0097113

GO:0097114

GO:0097117

GO:0098919

GO:0098978

GO:0099092

GO:0099562

GO:1900271

GO:1900273

GO:1900451

GO:1900452

GO:1904717

GO:2000311

GO:2000463

GO:2000821

GO:2000822

GO:2000969

ILMN_1215372

ILMN_3163115

mMC018524

Participates

as a member of

Inferred From

SHANK3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_067398.2

Ensembl

ENSMUSG00000022623, ENSMUSP00000104932, ENSMUSP00000155608, ENSMUST00000230807, ENSMUST00000109309

PRO

Q4ACU6

MGI

1930016

PDB

6KYH, 6KYK, 5IZU, 3O5N

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8BKX1	1	Baiap2 [cytosol] (R-MMU-442574)	0.708	6
UniProt:P63101 Ywhaz	3	14-3-3zeta [cytosol] (R-MMU-206177) Ywhaz [nucleoplasm] (R-MMU-450469) Ywhaz [cytosol] (R-MMU-206099)	0.643	3
UniProt:Q62108 Dlg4	2	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [cytosol] (R-MMU-6794267)	0.643	4
UniProt:A2CG49	2	phospho-Kalrn [cytosol] (R-MMU-5692652) Kalrn [cytosol] (R-MMU-3006505)	0.527	2
UniProt:P16546 Sptan1	6	Sptan1 [specific granule lumen] (R-MMU-6799533) Sptan1 [extracellular region] (R-MMU-6806322) Sptan1 [tertiary granule lumen] (R-MMU-6800874) Sptan1 [cytosol] (R-MMU-202964) Sptan1 [cytosol] (R-MMU-202944) Spectrin alpha chain, brain [cytosol] (R-MMU-681570)	0.527	2
UniProt:Q9WV60 Gsk3b	3	GSK3beta [cytosol] (R-MMU-206095) Gsk3b [nucleoplasm] (R-MMU-182565) Gsk3b [cytosol] (R-MMU-2997551)	0.527	2
UniProt:Q9Z1B3 Plcb1	2	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 [plasma membrane] (R-MMU-445858) Plcb1 [cytosol] (R-MMU-61693)	0.527	2
UniProt:Q02053	2	Uba1 [nucleoplasm] (R-MMU-8852116) Uba1 [cytosol] (R-MMU-947698)	0.527	2
UniProt:O88343	1	Slc4a4 [plasma membrane] (R-MMU-425545)	0.527	3
UniProt:Q8JZU2	1	Slc25a1 [mitochondrial inner membrane] (R-MMU-372445)	0.527	2
UniProt:P48453 Ppp3cb	3	Ppp3cb [cytosol] (R-MMU-2025962) Ppp3cb [nucleoplasm] (R-MMU-2685624) Ppp3cb [cytosol] (R-MMU-2025869)	0.527	2
UniProt:Q60932	3	Vdac1 [mitochondrial outer membrane] (R-MMU-6783079) Vdac1 [mitochondrial outer membrane] (R-MMU-1267988) Vdac1 [mitochondrial outer membrane] (R-MMU-5205624)	0.527	3