Dnmt3b:Dnmt3l methylates cytosine in DNA

Stable Identifier
R-MMU-5336380
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dnmt3b:Dnmt3l methylates cytosine in DNA
Dnmt3b methylates the 5 position of cytosine in DNA. Dnmt3b catalyzes de novo methylation of cytosine residues (Okano et al. 1998, Hsieh 1999) in CG sequences (Hsieh 1999) and in non-CG sequences (Arand et al. 2012). Methylation of C residues in non-CG contexts is observed only in embryonic stem cells and appears to be catalyzed by Dnmt3b and Dnmt3a acting with Dnmt3l (Arand et al. 2012).
Literature References
PubMed ID Title Journal Year
10567546 In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

Hsieh, CL

Mol. Cell. Biol. 1999
22761581 In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases

Arand, J, Spieler, D, Karius, T, Branco, MR, Meilinger, D, Meissner, A, Jenuwein, T, Xu, G, Leonhardt, H, Wolf, V, Walter, J

PLoS Genet. 2012
9662389 Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

Okano, M, Xie, S, Li, E

Nat. Genet. 1998
Participants
Input
Output
Catalyst Activity

DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of Dnmt3b:Dnmt3l:Chromatin [nucleoplasm]

Physical Entity
Dnmt3b:Dnmt3l:Chromatin [nucleoplasm] (Mus musculus)
Activity
DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates (GO:0051719)
Orthologous Events
DNMT3B:DNMT3L methylates cytosine in DNA (Homo sapiens)
Authored
May, B  (2014-02-22)
Reviewed
Beekman, R  (2014-07-24)
Martín-Subero, JI  (2014-07-24)
Created
May, B  (2014-03-02)
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