Fz3 asymmetric membrane localization depends on direct interaction with Vangl2

Stable Identifier
R-MMU-4608842
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Fz3 asymmetric membrane localization depends on direct interaction with Vangl2
Fz3 is asymmetrically localized in the membrane of the mouse inner ear in a pattern similar to that of Vangl2. Fz3 and Vangl2 interact directly in HEK293 cells and localization of Fz3 is lost in a Vangl2 mutant mouse (Montcouquiol et al, 2006).
Literature References
PubMed ID Title Journal Year
16687519 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M, Sans, N, Huss, D, Kach, J, Dickman, JD, Forge, A, Rachel, RA, Copeland, NG, Jenkins, NA, Bogani, D, Murdoch, J, Warchol, ME, Wenthold, RJ, Kelley, MW

J. Neurosci. 2006
Participants
Input
Output
Orthologous Events
VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)
Authored
Rothfels, K  (2013-09-14)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-23)
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