Fz3 asymmetric membrane localization depends on direct interaction with Vangl2

Stable Identifier
R-MMU-4608842
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Fz3 asymmetric membrane localization depends on direct interaction with Vangl2

Fz3 is asymmetrically localized in the membrane of the mouse inner ear in a pattern similar to that of Vangl2. Fz3 and Vangl2 interact directly in HEK293 cells and localization of Fz3 is lost in a Vangl2 mutant mouse (Montcouquiol et al, 2006).

Literature References
PubMed ID Title Journal Year
16687519 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M, Sans, N, Huss, D, Kach, J, Dickman, JD, Forge, A, Rachel, RA, Copeland, NG, Jenkins, NA, Bogani, D, Murdoch, J, Warchol, ME, Wenthold, RJ, Kelley, MW

J. Neurosci. 2006
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Orthologous Events
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