FZD3 shows an asymmetric distribution in the membrane of the mouse inner-ear sensory hair cells in a manner that depends on a direct interaction with VANGL2 (Montcouquiol et al, 2006). In this respect, the vertebrate PCP pathway differs from that of flies, where Vangl2 and Fz are localized to opposing membranes within a single cell (reviewed in Maung and Jenny, 2011). Note that although this reaction depicts a complex of VANGL2:FZD3 with SCRIB, the existence of this ternary complex has not been demonstrated.
Maung, SM, Jenny, A
Forge, A, Dickman, JD, Copeland, NG, Kelley, MW, Wenthold, RJ, Warchol, ME, Kach, J, Huss, D, Jenkins, NA, Sans, N, Bogani, D, Montcouquiol, M, Rachel, RA, Murdoch, J
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