FZD3 shows an asymmetric distribution in the membrane of the mouse inner-ear sensory hair cells in a manner that depends on a direct interaction with VANGL2 (Montcouquiol et al, 2006). In this respect, the vertebrate PCP pathway differs from that of flies, where Vangl2 and Fz are localized to opposing membranes within a single cell (reviewed in Maung and Jenny, 2011). Note that although this reaction depicts a complex of VANGL2:FZD3 with SCRIB, the existence of this ternary complex has not been demonstrated.
Montcouquiol, M, Sans, N, Huss, D, Kach, J, Dickman, JD, Forge, A, Rachel, RA, Copeland, NG, Jenkins, NA, Bogani, D, Murdoch, J, Warchol, ME, Wenthold, RJ, Kelley, MW
Maung, SM, Jenny, A
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