VANGL2 is required for asymmetric membrane localization of FZD3

Stable Identifier
R-HSA-4608866
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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VANGL2 is required for asymmetric membrane localization of FZD3
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FZD3 shows an asymmetric distribution in the membrane of the mouse inner-ear sensory hair cells in a manner that depends on a direct interaction with VANGL2 (Montcouquiol et al, 2006). In this respect, the vertebrate PCP pathway differs from that of flies, where Vangl2 and Fz are localized to opposing membranes within a single cell (reviewed in Maung and Jenny, 2011). Note that although this reaction depicts a complex of VANGL2:FZD3 with SCRIB, the existence of this ternary complex has not been demonstrated.

Literature References
PubMed ID Title Journal Year
16687519 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M, Sans, N, Huss, D, Kach, J, Dickman, JD, Forge, A, Rachel, RA, Copeland, NG, Jenkins, NA, Bogani, D, Murdoch, J, Warchol, ME, Wenthold, RJ, Kelley, MW

J. Neurosci. 2006
21983142 Planar cell polarity in Drosophila

Maung, SM, Jenny, A

Organogenesis 2011
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Fz3 asymmetric membrane localization depends on direct interaction with Vangl2 (Mus musculus)
Authored
Rothfels, K  (2013-09-14)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-23)