Scrib is required for Vangl2 asymmetric membrane localization in mouse

Stable Identifier
R-MMU-4608838
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Scrib is required for Vangl2 asymmetric membrane localization in mouse

Scrib and Vangl2 interact by yeast two hybrid and by co-immunoprecipitation in a manner that depends on the PDZ domains of both proteins. The asymmetric membrane localization of Vangl2 is significantly disrupted in a Scrib mutant mouse, suggesting a role for Scrib in targeting Vangl2 (Montcouquiol et al, 2006).

Literature References
PubMed ID Title Journal Year
16687519 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Montcouquiol, M, Sans, N, Huss, D, Kach, J, Dickman, JD, Forge, A, Rachel, RA, Copeland, NG, Jenkins, NA, Bogani, D, Murdoch, J, Warchol, ME, Wenthold, RJ, Kelley, MW

J. Neurosci. 2006
Participants
Orthologous Events
Authored
Reviewed
Created