Reactome | SCRIB is required for asymmetric membrane localization of VANGL2

SCRIB is required for asymmetric membrane localization of VANGL2

Stable Identifier

R-HSA-4608862

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SCRIB is required for asymmetric membrane localization of VANGL2

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VANGL2 is a core PCP protein. In Drosophila, asymmetric localization of Stbm (the fly VANGL homologue) and Fz to opposite membranes is a hallmark of the establishment of planar cell polarity (reviewed in Maung and Jenny, 2011). In the mouse inner-ear sensory hair cells, VANGL2 is also asymmetrically distributed in the membrane (Montcouquiol et al, 2003, 2006), and this distribution depends on a direct interaction with SCRIB, a peripheral membrane protein with no known role in fly PCP (reviewed in May-Simera and Kelley, 2012). Asymmetric VANGL2 localization in the mouse inner ear also depends on CELSR1, homologue to the Drosophila core PCP protein Flamingo, however a direct interaction between VANGL2 and CELSR1 has not been demonstrated (Montcouquiol et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
23140627	Planar cell polarity in the inner ear May-Simera, H, Kelley, MW	Curr. Top. Dev. Biol.	2012
12724779	Identification of Vangl2 and Scrb1 as planar polarity genes in mammals Montcouquiol, M, Copeland, NG, Kelley, MW, Lanford, PJ, Rachel, RA, Jenkins, NA	Nature	2003
21983142	Planar cell polarity in Drosophila Maung, SM, Jenny, A	Organogenesis	2011
16687519	Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals Forge, A, Dickman, JD, Copeland, NG, Kelley, MW, Wenthold, RJ, Warchol, ME, Kach, J, Huss, D, Jenkins, NA, Sans, N, Bogani, D, Montcouquiol, M, Rachel, RA, Murdoch, J	J. Neurosci.	2006