Vangl2 is phosphorylated in response to Wnt5a

Stable Identifier
R-MMU-4551572
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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PNG
Low
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 | PPTX  | SBGN
Vangl2 is phosphorylated in response to Wnt5a
Vangl2 is multiply phosphorylated on two clusters of serine and threonine residues in response to Wnt5a. Phosphorylation at serine 5, 82 and 84 appear to be required for more extensive phosphorylation at other positions. Overexpression of CK1delta promotes Vangl2 phosphorylation in CHO cells suggesting it may the activating kinase (Gao et al, 2011).
Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Song, H, Yang, Y, Garrett, L, Robinson, J, Economides, AN, Minami, Y, Bishop, K, English, MA, Gao, B, Sood, R, Andre, P, Elliot, G

Dev. Cell 2011
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)
Authored
Rothfels, K  (2013-09-12)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-14)
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